Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/6359
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kandaswamy K. | en_US |
dc.contributor.author | Guru A. | en_US |
dc.contributor.author | Panda S.P. | en_US |
dc.contributor.author | Antonyraj A.P.M. | en_US |
dc.contributor.author | Kari, Z.A. | en_US |
dc.contributor.author | Giri J. | en_US |
dc.contributor.author | Almutairi B.O. | en_US |
dc.contributor.author | Arokiyaraj S. | en_US |
dc.contributor.author | Malafaia G. | en_US |
dc.contributor.author | Arockiaraj J. | en_US |
dc.date.accessioned | 2024-08-21T09:19:14Z | - |
dc.date.available | 2024-08-21T09:19:14Z | - |
dc.date.issued | 2024-07 | - |
dc.identifier.issn | 15320456 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/6359 | - |
dc.description | Web of Science / Scopus | en_US |
dc.description.abstract | In this study, we investigated the possible ecotoxicological effect of co-exposure to polystyrene nanoplastics (PS-NPs) and diclofenac (DCF) in zebrafish (Danio rerio). After six days of exposure, we noticed that the co-exposure to PS-NP (100 μg/L) and DCF (at 50 and 500 μg/L) decreased the hatching rate and increased the mortality rate compared to the control group. Furthermore, we noted that larvae exposed to combined pollutants showed a higher frequency of morphological abnormalities and increased oxidative stress, apoptosis, and lipid peroxidation. In adults, superoxide dismutase and catalase activities were also impaired in the intestine, and the co-exposure groups showed more histopathological alterations. Furthermore, the TNF-α, COX-2, and IL-1β expressions were significantly upregulated in the adult zebrafish co-exposed to pollutants. Based on these findings, the co-exposure to PS-NPs and DCF has shown an adverse effect on the intestinal region, supporting the notion that PS-NPs synergistically exacerbate DCF toxicity in zebrafish. | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.relation.ispartof | Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology | en_US |
dc.subject | Aquatic pollution | en_US |
dc.subject | Biomarker | en_US |
dc.subject | Intestine | en_US |
dc.title | Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish | en_US |
dc.type | Printed | en_US |
dc.identifier.doi | 10.1016/j.cbpc.2024.109926 | - |
dc.volume | 281 | en_US |
dc.description.articleno | 109926 | en_US |
dc.description.type | Article | en_US |
item.grantfulltext | none | - |
item.openairetype | Printed | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Universiti Malaysia Kelantan | - |
Appears in Collections: | Faculty of Agro Based Industry - Journal (Scopus/WOS) |
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