Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/6224
DC Field | Value | Language |
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dc.contributor.author | Ravikumar O.V. | en_US |
dc.contributor.author | Marunganathan, Vanitha | en_US |
dc.contributor.author | Kumar, Meenakshi Sundaram Kishore | en_US |
dc.contributor.author | Mohan, Magesh | en_US |
dc.contributor.author | Shaik, Mohammed Rafi | en_US |
dc.contributor.author | Shaik, Baji | en_US |
dc.contributor.author | Guru, Ajay | en_US |
dc.contributor.author | Mat, K. | en_US |
dc.date.accessioned | 2024-08-06T03:29:02Z | - |
dc.date.available | 2024-08-06T03:29:02Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 03014851 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/6224 | - |
dc.description | Web of Science / Scopus | en_US |
dc.description.abstract | Background: Oral diseases are often attributed to dental pathogens such as S. aureus, S. mutans, E. faecalis, and C. albicans. In this research work, a novel approach was employed to combat these pathogens by preparing zinc oxide nanoparticles (ZnO NPs) capped with cinnamic acid (CA) plant compounds. Methods: The synthesized ZnO-CA NPs were characterized using SEM, FTIR, and XRD to validate their composition and structural features. The antioxidant activity of ZnO-CA NPs was confirmed using DPPH and ABTS free radical scavenging assays. The antimicrobial effects of ZnO-CA NPs were validated using a zone of inhibition assay against dental pathogens. Autodock tool was used to identify the interaction of cinnamic acid with dental pathogen receptors. Results: ZnO-CA NPs exhibited potent antioxidant activity in both DPPH and ABTS assays, suggesting their potential as powerful antioxidants. The minimal inhibitory concentration of ZnO-CA NPs against dental pathogens was found 25 µg/mL, indicating their effective antimicrobial properties. Further, ZnO-CA NPs showed better binding affinity and amino acid interaction with dental pathogen receptors. Also, the ZnO-CA NPs exhibited dose-dependent (5 µg/mL, 15 µg/mL, 25 µg/mL, and 50 µg/mL) anticancer activity against Human Oral Epidermal Carcinoma KB cells. The mechanism of action of apoptotic activity of ZnO-CA NPs on the KB cells was identified through the upregulation of BCL-2, BAX, and P53 genes. Conclusions: This research establishes the potential utility of ZnO-CA NPs as a promising candidate for dental applications. The potent antioxidant, anticancer, and effective antimicrobial properties of ZnO-CA NPs make them a valuable option for combating dental pathogens. | en_US |
dc.publisher | Springer Science and Business Media B.V. | en_US |
dc.relation.ispartof | Molecular Biology Reports | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Cinnamic acid | en_US |
dc.subject | zinc oxide nanoparticle | en_US |
dc.title | Zinc oxide nanoparticles functionalized with cinnamic acid for targeting dental pathogens receptor and modulating apoptotic genes in human oral epidermal carcinoma KB cells | en_US |
dc.type | International | en_US |
dc.identifier.doi | 10.1007/s11033-024-09289-9 | - |
dc.volume | 51(1) | en_US |
dc.description.articleno | 352 | en_US |
dc.description.type | Article | en_US |
dc.contributor.correspondingauthor | khairiyah@umk.edu.my | en_US |
item.grantfulltext | none | - |
item.openairetype | International | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Faculty of Agro Based Industry - Journal (Scopus/WOS) |
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