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Title: | Protective effects of feed additives on broiler chickens exposed to aflatoxins-contaminated feed: a systematic review and meta-analysis | Authors: | Putra, R.P. Astuti, D. Respati, A.N. Ningsih, N. Triswanto Yano, A.A. Gading, B.M.W.T. Jayanegara, A. Sholikin, M.M. Hassim, H.A. Azmi, A.F.M Irawan, A. |
Keywords: | Aflatoxin B1;Feed contamination;Feed additive;Network meta-analysis;Broiler chickens | Issue Date: | 2023 | Publisher: | Springer Science and Business Media B.V. | Journal: | Veterinary Research Communications | Abstract: | Aflatoxin contamination in feed is a common problem in broiler chickens. The present systematic review and meta-analysis examined the impact of aflatoxin-contaminated feed and the efficacy of various feed additives on the production performance of broiler chickens fed aflatoxin-contaminated feed (AF-feed). A total of 35 studies comprising 53 AF-feed experiments were selected following PRISMA guidelines. Feed additives included in the analyses were toxins binder (TB), mannan- oligosaccharides (MOS), organic acid (OA), probiotics (PRO), protein supplementation (PROT), phytobiotics (PHY), and additive mixture (MIX). Random effects model and a frequentist network meta-analysis (NMA) were performed to rank the efficacy of feed additives, reported as standardized means difference (SMD) at 95% confidence intervals (95% CI). Overall, broiler chickens fed AF-feed had significantly lower final body weight (BW) (SMD = 198; 95% CI = 198 to 238) and higher feed conversion ratio (SMD = 0.17; 95% CI = 0.13 to 0.21) than control. Treatments with TB, MOS, and PHY improved the BW of birds fed AF-feed (P < 0.05) to be comparable with non-contaminated feed or control. Predictions on final BW from the broiler-fed aflatoxin-contaminated diet were 15% lower than the control diet. Including feed additives in the aflatoxins diet could ameliorate the depressive effect. Remarkably, our network meta-analysis highlighted that TB was the highest- performing additive (P-score = 0.797) to remedy aflatoxicosis. Altogether, several additives, especially TB, are promising to ameliorate aflatoxicosis in broiler chickens, although the efficacy was low regarding the severity of the aflatoxicosis. |
Description: | Web of Science / Scopus |
URI: | http://hdl.handle.net/123456789/5986 | ISSN: | 01657380 | DOI: | 10.1007/s11259-023-10199-7 |
Appears in Collections: | Faculty of Veterinary Medicine - Journal (Scopus/WOS) |
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s11259-023-10199-7.pdf | paper | 2.15 MB | Adobe PDF | View/Open |
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