Microwave assisted synthesis of imidazolyl fluorescent dyes as antimicrobial agents

Abstract

In this article, we report, the synthesis and characterization of series of novel fluorescentimidazolyl dyes (5a-d) via highly efficient and cost-effective microwave assisted protocol asa potential candidate to overcome the problem of microbial resistance. By utilizing the greenmicrowave protocol the reactions are completed in a short span of time without using theharsh conditions. The incorporation of imidazole nucleus is an important strategy in drugdiscovery. While designing desired fluorescent imidazole dyes 5a-d, with a suitable auxiliarydonor such as aromatic rings and -OCH3group on one end of the imidazolyl moiety andelectron acceptors such as -NO2and -COOH on other end of the compounds was achievedto get a promising fluorescent dyes for antimicrobial. The optoelectronic properties andantimicrobial studies of the synthesized materials indicated their exploration as a promisingcandidate as antimicrobial agents