Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/5262
DC Field | Value | Language |
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dc.contributor.author | Nisansala, T. | en_US |
dc.contributor.author | Weerasekera, M | en_US |
dc.contributor.author | Ranasinghe, N | en_US |
dc.contributor.author | Gamage, C | en_US |
dc.contributor.author | Marasinghe, C | en_US |
dc.contributor.author | Fernando, N | en_US |
dc.contributor.author | Gunasekara, C | en_US |
dc.date.accessioned | 2023-12-27T04:34:10Z | - |
dc.date.available | 2023-12-27T04:34:10Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/5262 | - |
dc.description | Web of Science | en_US |
dc.description.abstract | Introduction: Intro Leptospirosis is a re-emerging zoonosis endemic to Sri Lanka. Considerable variation is seen in the clinical manifestations among leptospirosis patients and spectrum ranges from uncomplicated febrile illness to multi-organ failure and death. Therefore, this study aimed to identify severity predictors among a leptospirosis cohort in Sri Lanka. Method: This was a prospective hospital-based study carried out during 2017 in 2 selected hospitals in Western province of Sri Lanka. Clinically suspected leptospirosis patients were enrolled according to Communicable Disease Epidemiology Profile, WHO. Leptospirosis was confirmed by MAT titer ≥1:320, culture or by polymerase chain reaction. Leptospirosis confirmed patients were divided into patients with and without complications based on acute kidney injury, pulmonary hemorrhage, myocarditis and liver failure. Findings: Among 79 leptospirosis confirmed patients, a total of 28 (35.44%) patients developed complications. The mean age of patients was 45.05±16.19 and most were males (87.34%). The major complications were acute kidney injury (68%), pulmonary hemorrhage (36%), liver failure (36%) and myocarditis (14%). Having dyspnea (OR-7.10; CI-1.31-38.42; p=0.023), icterus (OR-6.45; CI1.72-24.05; p=0.006), oliguria (OR-5.22; CI-1.87-14.59; p=0.002) and cardiac arrythmias (OR-5.92; CI1.05-33.24; p=0.043) as clinical manifestations on admission were significantly associated with leptospirosis complications. Further patients with white blood cell >11,000 mm3 (OR-3.64; CI-1.34-9.86; p=0.011), neutrophil >75% (OR-13.41; CI-1.66- 108.10; p=0.015), serum glutamicoxaloacetic transaminase >40 U/L (OR-5.89; CI-1.21-28.53; p=0.028), serum creatinine >120 μmol/L (OR-29.14; CI-6.05-140.22; p6.5 mmol/L (OR-15.00; CI-1.82-123.56; p=0.012) and total bilirubin >21 μmol/L (OR15.20; CI-3.48-66.33; p<0.001) in laboratory investigation were defined as independent risk factors among patients with complications. Conclusion: Identified clinical and laboratory parameters can help clinicians to rapidly identify patients at risk of developing complications of leptospirosis, prompting aggressive treatment, advanced supportive care and close monitoring. | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | International Society for Infectious Diseases | en_US |
dc.subject | Leptospirosis | en_US |
dc.title | Predictors of Severe Leptospirosis on Admission: A Sri Lankan Study | en_US |
dc.type | International | en_US |
dc.identifier.doi | 10.1016/j.ijid.2023.05.067 | - |
dc.description.page | S18-S19 | en_US |
dc.volume | 134 | en_US |
dc.description.type | Meeting Abstract | en_US |
dc.description.impactfactor | 8.4 | en_US |
dc.description.quartile | Q1 | en_US |
item.grantfulltext | open | - |
item.openairetype | International | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Veterinary Medicine, Universiti Malaysia Kelantan | - |
Appears in Collections: | Faculty of Veterinary Medicine - Journal (Scopus/WOS) |
Files in This Item:
File | Description | Size | Format | |
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PREDICTORS OF SEVERE LEPTOSPIROSIS ON ADMISSION_ A SRI LANKAN STUDY.pdf | 417.39 kB | Adobe PDF | View/Open |
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