Development of Piper betle nanoemulgel formulation for effective droplet size reduction and excellent stability

Abstract

The goal of this research is to formulate and evaluate the current potential of the nanoemulgel which incorporate the natural plant essential oil as central ingredient for effective topical drug delivery system. In general, the nanoemulgel comprise of two different manners which the nanoemulsion contains the active ingredient then embody into the gel base system. In this research, Piper betle essential oil had been chosen to be as the active element in the formulation and the steam distillation had been carried out to extract the essential oil. The nanoemulsion consists of two immiscible phases such as soy bean oil as oil phase, distilled water as aqueous phase and tween 80 as surfactant with Glycerol as co-surfactant. Carbopol 940 is employed as gelling agent to increase the viscosity of the formulation of the nanoemulgel. In this research, different ratio of the nanoemulsion and nanoemulgel had been formulated and investigated for few characteristics such as droplet size, viscosity, pH and spreadability. The droplet size of nanoemulsion was determined with Dynamic light scattering (DLS) and in the range of35.91 nm to 747.27 nm. Besides, pH of the nanoemulsions and nanoemulgels were in the range of 5.5 to 6.9, which is nearly neutral. Plant derived nanoemulgel has been becoming the increasing trend applied in field applications because of their few unique characteristics such as non-toxic, better spreadability, non-greasy, and so on. In short, P. betle nanoemulgel presented as a potential and promising manner in topical drug delivery in the future