Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2119
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dc.contributor.authorVendidandala, NRen_US
dc.contributor.authorYin, TPen_US
dc.contributor.authorNelli, Gen_US
dc.contributor.authorPasupuleti, VRen_US
dc.contributor.authorNyamathulla, Sen_US
dc.contributor.authorMokhtar, S. I.en_US
dc.date.accessioned2022-01-01T05:49:39Z-
dc.date.available2022-01-01T05:49:39Z-
dc.date.issued2021-12-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/123456789/2119-
dc.descriptionWeb of Scienceen_US
dc.description.abstractThis study is designed to investigate the combination of gallocatechin (GC) and silver nanoparticles (AgNPs) for its wound healing ability in diabetic rats. Thirty male Sprague Dawley rats were randomly divided into 5 groups: 1. Normal control rats dressed with blank CGP1; 2. Diabetic rats dressed with blank CGP1; 3. Diabetic rats dressed with 13.06 mu M of GC; 4. Diabetic rats dressed with 26.12 mu M of GC; 5. Diabetic rats dressed with 0.1% silver sulfadiazine patches. GC-AgNPs-CGP dressed diabetic rats showed significant FBG reduction, prevented the body weight losses and reduced the oxidative stress by lowering MDA content and elevated antioxidant enzymes such as SOD, CAT and GPx in wound healing skin of diabetic rats when compared to normal CGP. Besides, mRNA expression of Nrf2, Nqo-1, and Ho-1 was upregulated with downregulated expression of Keap-1 mRNA, which is supported by immunohistochemistry. Furthermore, GC-AgNPs-CGP dressing increased growth factors such as VEGF, EGF, TGF-beta, and FGF-2 while decreasing MMP-2 in the skin of diabetic wound rats. In vitro permeation study demonstrated rapid GC release and permeation with a flux of 0.061 and 0.143 mg/sq.cm/h. In conclusion, the results indicated that GC-AgNPs-CGP dressing on diabetic wound rats modulated oxidative stress and inflammation with elevated growth factors; increased collagen synthesis thereby significantly improved the wound healing and could be beneficial for the management of diabetic wounds.en_US
dc.relation.ispartofLIFE SCIENCESen_US
dc.subjectWound healingen_US
dc.subjectDiabetes mellitusen_US
dc.subjectGallocatechinen_US
dc.titleGallocatechin-silver nanoparticle impregnated cotton gauze patches enhance wound healing in diabetic rats by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-kappa B pathwaysen_US
dc.typeInternationalen_US
dc.identifier.doi10.1016/j.lfs.2021.120019-
dc.volume286en_US
dc.description.typeArticleen_US
dc.description.impactfactor5.037en_US
dc.description.quartileQ1en_US
dc.contributor.correspondingauthorintan@umk.edu.myen_US
item.grantfulltextnone-
item.openairetypeInternational-
item.fulltextNo Fulltext-
Appears in Collections:Faculty of Agro Based Industry - Journal (Scopus/WOS)
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